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Sigma
Clofibrate
C6643 -
liquid
DOWNLOAD MSDS (PDF)Synonym: 2-
CAS Number: 637-07-0
Empirical Formula (Hill Notation): C12H15ClO3
Molecular Weight: 242.70
Beilstein Registry Number: 1913459
EC Number: 211-277-4
MDL number: MFCD00000615
PubChem Substance ID: 24278085
Properties
| Related Categories | Bioactive Small Molecules, CI-CY, Cell Biology, Cell Signaling and Neuroscience, Cholesterol and Cholesterol Metabolism, |
| form | liquid |
| color | clear, colorless |
| density | 1.14 g/mL at 25 °C(lit.) |
| storage temp. | 2-8°C |
| Gene Information | Research your gene in Your Favorite Gene powered by Ingenuity human ... PPARA(5465) mouse ... Ppara(19013) |
Description
Biochem/physiol Actions
Peroxisome proliferator-activated receptor-α (PPARα) agonist. Antihyperlipoproteinemic believed to act by inhibiting cholesterol biosynthesis.
Packaging
1, 5, 10 g in glass btl
250 mg in glass btl
Price and Availability
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Safety Information
| Symbol |   GHS05, GHS07 |
| Signal word | Danger |
| Hazard statements | H302-H315-H318-H335 |
| Precautionary statements | P261-P280-P305 + P351 + P338 |
| Personal Protective Equipment | Eyeshields, Faceshields, full-face respirator (US), Gloves, multi-purpose combination respirator cartridge (US), type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn,N |
| Risk Statements | 22-37/38-41-51/53 |
| Safety Statements | 26-36/37/39-61 |
| RIDADR | UN 3082 9/PG 3 |
| WGK Germany | 3 |
| RTECS | UE9480000 |
| Flash Point(F) | 235.4 °F |
| Flash Point(C) | 113 °C |
Technical information & documentation associated with this product is available in the Safety & Documentation tab.
Articles
Cholesterol Biosynthesis Regulation
The amount of cholesterol that is synthesized in the liver is tightly regulated by dietary cholesterol levels. When dietary intake of cholesterol is high, synthesis is decreased and when dietary inta...
BioFiles 2007, 2.7, 6.
Keywords: Gene expression, PAGE, Transcription
References
Buchmann, A., et al., Inhibition of transforming growth factor beta1-induced hepatoma cell apoptosis by liver tumor promoters: characterization of primary signaling events and effects on CPP32-like caspase activity. Cell Death Differ. 6, 190, (1999) Abstract
Karbowska, J., Tissue-specific effect of clofibrate on rat lipogenic enzyme gene expression. Eur. J. Pharmacol. 370, 329, (1999) Abstract
Knopp, R.H., et al., Drug treatment of lipid disorders. New Engl. J. Med. 341, 498, (1999) Abstract
Merck 14,2377
Beil. 6,IV,851
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